A Complex Interplay of Anionic Phospholipid Binding Regulates 3′-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation

3′-Phosphoinositide-dependent-Kinase-1 (PDK1) is a master regulator whereby its PI3-kinase-dependent dysregulation in human pathologies is well documented. Understanding the direct role for PtdIns(3,4,5)P(3) and other anionic phospholipids in the regulation of PDK1 conformational dynamics and its do...

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Detalles Bibliográficos
Autores principales: Heras-Martínez, Gloria de las, Calleja, Véronique, Bailly, Remy, Dessolin, Jean, Larijani, Banafshé, Requejo-Isidro, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787260/
https://www.ncbi.nlm.nih.gov/pubmed/31601855
http://dx.doi.org/10.1038/s41598-019-50742-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787260/
https://www.ncbi.nlm.nih.gov/pubmed/31601855
http://dx.doi.org/10.1038/s41598-019-50742-8

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