Cargando…
Conservation of Atypical Allostery in C. elegans UDP-Glucose Dehydrogenase
[Image: see text] Human UDP-glucose dehydrogenase (hUGDH) oxidizes uridine diphosphate (UDP)-glucose to UDP-glucuronic acid, an essential substrate in the phase II metabolism of drugs. The activity of hUGDH is controlled by an atypical allosteric mechanism in which the feedback inhibitor UDP-xylose...
Autores principales: | Beattie, Nathaniel R., Keul, Nicholas D., Hicks Sirmans, Tiffany N., McDonald, Weston E., Talmadge, Trevor M., Taujale, Rahil, Kannan, Natarajan, Wood, Zachary A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788056/ https://www.ncbi.nlm.nih.gov/pubmed/31616809 http://dx.doi.org/10.1021/acsomega.9b01565 |
Ejemplares similares
-
Evolution of Functional Diversity in the Holozoan Tyrosine Kinome
por: Yeung, Wayland, et al.
Publicado: (2021) -
Evolution of allostery in the cyclic nucleotide binding module
por: Kannan, Natarajan, et al.
Publicado: (2007) -
Mapping the glycosyltransferase fold landscape using interpretable deep learning
por: Taujale, Rahil, et al.
Publicado: (2021) -
Cloning, Expression and Characterization of UDP-Glucose Dehydrogenases
por: Couto, Márcia R., et al.
Publicado: (2021) -
Peters plus syndrome mutations affect the function and stability of human β1,3-glucosyltransferase
por: Zhang, Ao, et al.
Publicado: (2021)