Probing the limits of Q-tag bioconjugation of antibodies

Site-selective labelling of antibodies (Abs) can circumvent problems from heterogeneity of conventional conjugation. Here, we evaluate the industrially-applied chemoenzymatic ‘Q-tag’ strategy based on transglutaminase-mediated (TGase) amide-bond formation in the generation of (89)Zr-radiolabelled an...

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Detalles Bibliográficos
Autores principales: Marculescu, Cristina, Lakshminarayanan, Abirami, Gault, Joseph, Knight, James C., Folkes, Lisa K., Spink, Thomas, Robinson, Carol V., Vallis, Katherine, Davis, Benjamin G., Cornelissen, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788405/
https://www.ncbi.nlm.nih.gov/pubmed/31479092
http://dx.doi.org/10.1039/c9cc02303h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788405/
https://www.ncbi.nlm.nih.gov/pubmed/31479092
http://dx.doi.org/10.1039/c9cc02303h

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