Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire

OBJECTIVE: To gain more insight into the dynamics of lymphocyte depletion and develop new predictors of clinical response to rituximab in rheumatoid arthritis (RA). METHODS: RNA-based next-generation sequencing was used to analyse the B cell receptor (BCR) repertoire in peripheral blood and synovial...

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Detalles Bibliográficos
Autores principales: Pollastro, Sabrina, Klarenbeek, Paul L, Doorenspleet, Marieke E, van Schaik, Barbera D C, Esveldt, Rebecca E E, Thurlings, Rogier M, Boumans, Maria J H, Gerlag, Danielle M, Tak, Paul P, Vos, Koen, Baas, Frank, van Kampen, Antoine H C, de Vries, Niek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Rheumatoid Arthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788876/
https://www.ncbi.nlm.nih.gov/pubmed/31217169
http://dx.doi.org/10.1136/annrheumdis-2018-214898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788876/
https://www.ncbi.nlm.nih.gov/pubmed/31217169
http://dx.doi.org/10.1136/annrheumdis-2018-214898

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