Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

OBJECTIVES: Genetic variations in TNFAIP3 (A20) de-ubiquitinase (DUB) domain increase the risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis. A20 is a negative regulator of NF-κB but the role of its DUB domain and related genetic variants remain unclear. We aimed to study the functi...

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Detalles Bibliográficos
Autores principales: Odqvist, Lina, Jevnikar, Zala, Riise, Rebecca, Öberg, Lisa, Rhedin, Magdalena, Leonard, Dag, Yrlid, Linda, Jackson, Sonya, Mattsson, Johan, Nanda, Sambit, Cohen, Philip, Knebel, Axel, Arthur, Simon, Thörn, Kristofer, Svenungsson, Elisabet, Jönsen, Andreas, Gunnarsson, Iva, Tandre, Karolina, Alexsson, Andrei, Kastbom, Alf, Rantapää-Dahlqvist, Solbritt, Eloranta, Maija-Leena, Syvänen, Ann-Christine, Bengtsson, Anders, Johansson, Patrik, Sandling, Johanna K, Sjöwall, Christopher, Rönnblom, Lars, Collins, Barry, Vaarala, Outi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Systemic Lupus Erythematosus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788882/
https://www.ncbi.nlm.nih.gov/pubmed/31300459
http://dx.doi.org/10.1136/annrheumdis-2019-215434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788882/
https://www.ncbi.nlm.nih.gov/pubmed/31300459
http://dx.doi.org/10.1136/annrheumdis-2019-215434

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