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Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
OBJECTIVES: Genetic variations in TNFAIP3 (A20) de-ubiquitinase (DUB) domain increase the risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis. A20 is a negative regulator of NF-κB but the role of its DUB domain and related genetic variants remain unclear. We aimed to study the functi...
Autores principales: | Odqvist, Lina, Jevnikar, Zala, Riise, Rebecca, Öberg, Lisa, Rhedin, Magdalena, Leonard, Dag, Yrlid, Linda, Jackson, Sonya, Mattsson, Johan, Nanda, Sambit, Cohen, Philip, Knebel, Axel, Arthur, Simon, Thörn, Kristofer, Svenungsson, Elisabet, Jönsen, Andreas, Gunnarsson, Iva, Tandre, Karolina, Alexsson, Andrei, Kastbom, Alf, Rantapää-Dahlqvist, Solbritt, Eloranta, Maija-Leena, Syvänen, Ann-Christine, Bengtsson, Anders, Johansson, Patrik, Sandling, Johanna K, Sjöwall, Christopher, Rönnblom, Lars, Collins, Barry, Vaarala, Outi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788882/ https://www.ncbi.nlm.nih.gov/pubmed/31300459 http://dx.doi.org/10.1136/annrheumdis-2019-215434 |
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