The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway

The mut-T homolog-1 (MTH1) inhibitor TH588 has shown promise in preclinical cancer studies but its targeting specificity has been questioned. Alternative mechanisms for the anti-cancer effects of TH588 have been suggested but the question remains unresolved. Here, we performed an unbiased CRISPR scr...

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Detalles Bibliográficos
Autores principales: Gul, Nadia, Karlsson, Joakim, Tängemo, Carolina, Linsefors, Sanna, Tuyizere, Samuel, Perkins, Rosie, Ala, Chandu, Zou, Zhiyuan, Larsson, Erik, Bergö, Martin O., Lindahl, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789014/
https://www.ncbi.nlm.nih.gov/pubmed/31604991
http://dx.doi.org/10.1038/s41598-019-51205-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789014/
https://www.ncbi.nlm.nih.gov/pubmed/31604991
http://dx.doi.org/10.1038/s41598-019-51205-w

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