Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity

This study investigated the potential of vitamin K1 as a novel lens aldose reductase inhibitor in a streptozotocin-induced diabetic cataract model. A single, intraperitoneal injection of streptozotocin (STZ) (35 mg/kg) resulted in hyperglycemia, activation of lens aldose reductase 2 (ALR2) and accum...

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Detalles Bibliográficos
Autores principales: Thiagarajan, R., Varsha, M. K. N. Sai, Srinivasan, V., Ravichandran, R., Saraboji, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789135/
https://www.ncbi.nlm.nih.gov/pubmed/31604989
http://dx.doi.org/10.1038/s41598-019-51059-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789135/
https://www.ncbi.nlm.nih.gov/pubmed/31604989
http://dx.doi.org/10.1038/s41598-019-51059-2

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