Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

Cytosolic mitochondrial DNA (mtDNA) activates cGAS-mediated antiviral immune responses, but the mechanism by which RNA viruses stimulate mtDNA release remains unknown. Here we show that viroporin activity of influenza virus M2 or encephalomyocarditis virus (EMCV) 2B protein triggers translocation of...

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Detalles Bibliográficos
Autores principales: Moriyama, Miyu, Koshiba, Takumi, Ichinohe, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789137/
https://www.ncbi.nlm.nih.gov/pubmed/31604929
http://dx.doi.org/10.1038/s41467-019-12632-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789137/
https://www.ncbi.nlm.nih.gov/pubmed/31604929
http://dx.doi.org/10.1038/s41467-019-12632-5

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