ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

Reduced BRCA1 expression causes homologous recombination (HR) repair defects in high-grade serous ovarian cancers (HGSOCs). Here, we demonstrate that BRCA1 is transcriptionally activated by a previously unknown function of ZC3H18. We show that ZC3H18 is a DNA-binding protein that interacts with an E...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanakkanthara, Arun, Huntoon, Catherine J., Hou, Xiaonan, Zhang, Minzhi, Heinzen, Ethan P., O’Brien, Daniel R., Oberg, Ann L., John Weroha, S., Kaufmann, Scott H., Karnitz, Larry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789141/
https://www.ncbi.nlm.nih.gov/pubmed/31604914
http://dx.doi.org/10.1038/s41467-019-12610-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789141/
https://www.ncbi.nlm.nih.gov/pubmed/31604914
http://dx.doi.org/10.1038/s41467-019-12610-x

Ejemplares similares