Cargando…

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

Reduced BRCA1 expression causes homologous recombination (HR) repair defects in high-grade serous ovarian cancers (HGSOCs). Here, we demonstrate that BRCA1 is transcriptionally activated by a previously unknown function of ZC3H18. We show that ZC3H18 is a DNA-binding protein that interacts with an E...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kanakkanthara, Arun, Huntoon, Catherine J., Hou, Xiaonan, Zhang, Minzhi, Heinzen, Ethan P., O’Brien, Daniel R., Oberg, Ann L., John Weroha, S., Kaufmann, Scott H., Karnitz, Larry M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789141/ https://www.ncbi.nlm.nih.gov/pubmed/31604914 http://dx.doi.org/10.1038/s41467-019-12610-x

Ejemplares similares

VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases
por: Ekstrom, Thomas L., et al.
Publicado: (2021)

Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma
por: Kanakkanthara, Arun, et al.
Publicado: (2022)

RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
por: Geng, Liyi, et al.
Publicado: (2010)

BRCA2 and homologous recombination
por: Orelli, Brian J, et al.
Publicado: (2001)

Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A
por: Torres, Diogo, et al.
Publicado: (2019)

The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination
por: Wu, Duo, et al.
Publicado: (2023)

BRCA2 Promotes Spontaneous Homologous Recombination In Vivo
por: Brown, Adam D., et al.
Publicado: (2021)

PRPF8 is important for BRCA1-mediated homologous recombination
por: Onyango, David O., et al.
Publicado: (2017)

Checkpoint Signaling, Base Excision Repair, and PARP Promote Survival of Colon Cancer Cells Treated with 5-Fluorodeoxyuridine but Not 5-Fluorouracil
por: Geng, Liyi, et al.
Publicado: (2011)

Antagonism between BRCA2 and FIGL1 regulates homologous recombination
por: Kumar, Rajeev, et al.
Publicado: (2019)

BRCA1 and homologous recombination: implications from mouse embryonic development
por: Liu, Yidan, et al.
Publicado: (2020)

Biallelic BRCA Loss and Homologous Recombination Deficiency in Nonbreast/Ovarian Tumors in Germline BRCA1/2 Carriers
por: Wineland, Dylane, et al.
Publicado: (2023)

Technology of Manufacturing of ZC Cylindrical Worm
por: Boral, Piotr, et al.
Publicado: (2022)

A Systematic Review and Meta-Analysis on the Prognostic Value of BRCA Mutations, Homologous Recombination Gene Mutations, and Homologous Recombination Deficiencies in Cancer
por: Shao, Changxia, et al.
Publicado: (2022)

Requirement of Heterogeneous Nuclear Ribonucleoprotein C for BRCA Gene Expression and Homologous Recombination
por: Anantha, Rachel W., et al.
Publicado: (2013)

Accurate quantification of homologous recombination in zebrafish: brca2 deficiency as a paradigm
por: Vierstraete, Jeroen, et al.
Publicado: (2017)

Homologous Recombination Deficiency Testing for BRCA-Like Tumors: The Road to Clinical Validation
por: Ladan, Marjolijn M., et al.
Publicado: (2021)

Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress
por: Kelly, Rebecca L., et al.
Publicado: (2022)

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
por: Parvin, Jeffrey, et al.
Publicado: (2011)

The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination
por: Qing, Yong, et al.
Publicado: (2011)

Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2012)

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks
por: Willis, Nicholas A., et al.
Publicado: (2014)

A second DNA binding site in human BRCA2 promotes homologous recombination
por: von Nicolai, Catharina, et al.
Publicado: (2016)

ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
por: Xu, Shibin, et al.
Publicado: (2021)

ZC3H12B/MCPIP2, a new active member of the ZC3H12 family
por: Wawro, Mateusz, et al.
Publicado: (2019)

Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity
por: Zhang, Dangquan, et al.
Publicado: (2020)

Development of a Serological Assay for the Sea Lion (Zalophus californianus) Anellovirus, ZcAV
por: Fahsbender, Elizabeth, et al.
Publicado: (2015)

Statistical analysis of comparative tumor growth repeated measures experiments in the ovarian cancer patient derived xenograft (PDX) setting
por: Oberg, Ann L., et al.
Publicado: (2021)

REV1 and polymerase ζ facilitate homologous recombination repair
por: Sharma, Shilpy, et al.
Publicado: (2012)

Homologous Recombination Deficiency Landscape of Breast Cancers and Real-World Effectiveness of Poly ADP-Ribose Polymerase Inhibitors in Patients With Somatic BRCA1/2, Germline PALB2, or Homologous Recombination Deficiency Signature
por: Batalini, Felipe, et al.
Publicado: (2023)

DAGBagM: learning directed acyclic graphs of mixed variables with an application to identify protein biomarkers for treatment response in ovarian cancer
por: Chowdhury, Shrabanti, et al.
Publicado: (2022)

Syk-dependent alternative homologous recombination activation promotes cancer resistance to DNA targeted therapy
por: Zhou, Qin, et al.
Publicado: (2023)

A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination
por: Luo, Kuntian, et al.
Publicado: (2016)

Search for exclusive photoproduction of $Z_c(3900)$ at COMPASS
por: Guskov, Alexey
Publicado: (2015)

Constitutive hyperproduction of sorbicillinoids in Trichoderma reesei ZC121
por: Li, Chengcheng, et al.
Publicado: (2018)

RecX Facilitates Homologous Recombination by Modulating RecA Activities
por: Cárdenas, Paula P., et al.
Publicado: (2012)

EXD2 promotes homologous recombination by facilitating DNA-end resection
por: Broderick, Ronan, et al.
Publicado: (2016)

TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair
por: Hariharasudhan, Gurusamy, et al.
Publicado: (2022)

BRCC36A is epistatic to BRCA1 in DNA crosslink repair and homologous recombination in Arabidopsis thaliana
por: Block-Schmidt, Astrid S., et al.
Publicado: (2011)

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains
por: Siaud, Nicolas, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_cqpp4er935nolins34gu01vfpv