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Shortened nuclear matrix attachment regions are sufficient for replication and maintenance of episomes in mammalian cells

Matrix attachment regions (MARs) can mediate the replication of vector episomes in mammalian cells; however, the molecular mode of action remains unclear. Here, we assessed the characteristics of MARs and the mechanism that mediates episomal vector replication in mammalian cells. Five shortened subf...

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Detalles Bibliográficos
Autores principales: Wang, Xiao-Yin, Zhang, Xi, Wang, Tian-Yun, Jia, Yan-Long, Xu, Dan-Hua, Yi, Dan-Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789156/
https://www.ncbi.nlm.nih.gov/pubmed/31509492
http://dx.doi.org/10.1091/mbc.E19-02-0108