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Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment
Stable localization of the Rheb GTPase to lysosomes is thought to be required for activation of mTOR complex 1 (mTORC1) signaling. However, the lysosome targeting mechanisms for Rheb remain unclear. We therefore investigated the relationship between Rheb subcellular localization and mTORC1 activatio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789162/ https://www.ncbi.nlm.nih.gov/pubmed/31532697 http://dx.doi.org/10.1091/mbc.E19-03-0146 |