Cytotoxicity of 1-deoxysphingolipid unraveled by genome-wide genetic screens and lipidomics in Saccharomyces cerevisiae

Hereditary sensory and autonomic neuropathy (HSAN) types IA and IC (IA/C) are caused by elevated levels of an atypical class of lipid named 1-deoxysphingolipid (DoxSL). How elevated levels of DoxSL perturb the physiology of the cell and how the perturbations lead to HSAN IA/C are largely unknown. In...

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Detalles Bibliográficos
Autores principales: Haribowo, A. Galih, Hannich, J. Thomas, Michel, Agnès H., Megyeri, Márton, Schuldiner, Maya, Kornmann, Benoît, Riezman, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789163/
https://www.ncbi.nlm.nih.gov/pubmed/31509475
http://dx.doi.org/10.1091/mbc.E19-07-0364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789163/
https://www.ncbi.nlm.nih.gov/pubmed/31509475
http://dx.doi.org/10.1091/mbc.E19-07-0364

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