The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function

Polypeptide N-acetylgalactosaminyl transferases (GalNAc-Ts) initiate mucin type O-glycosylation by catalyzing the transfer of N-acetylgalactosamine (GalNAc) to Ser or Thr on a protein substrate. Inactive and partially active variants of the isoenzyme GalNAc-T12 are present in subsets of patients wit...

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Detalles Bibliográficos
Autores principales: Fernandez, Amy J., Daniel, Earnest James Paul, Mahajan, Sai Pooja, Gray, Jeffrey J., Gerken, Thomas A., Tabak, Lawrence A., Samara, Nadine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789641/
https://www.ncbi.nlm.nih.gov/pubmed/31548401
http://dx.doi.org/10.1073/pnas.1902211116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789641/
https://www.ncbi.nlm.nih.gov/pubmed/31548401
http://dx.doi.org/10.1073/pnas.1902211116

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