Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis

cis-Aconitate decarboxylase (CAD, also known as ACOD1 or Irg1) converts cis-aconitate to itaconate and plays central roles in linking innate immunity with metabolism and in the biotechnological production of itaconic acid by Aspergillus terreus. We have elucidated the crystal structures of human and...

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Detalles Bibliográficos
Autores principales: Chen, Fangfang, Lukat, Peer, Iqbal, Azeem Ahmed, Saile, Kyrill, Kaever, Volkhard, van den Heuvel, Joop, Blankenfeldt, Wulf, Büssow, Konrad, Pessler, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789909/
https://www.ncbi.nlm.nih.gov/pubmed/31548418
http://dx.doi.org/10.1073/pnas.1908770116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789909/
https://www.ncbi.nlm.nih.gov/pubmed/31548418
http://dx.doi.org/10.1073/pnas.1908770116

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