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MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions
scRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique cell that can never be resampled, and robust analysis must separate the sampling effect from biological variance. We describe a methodology for partitioning scRNA-seq datasets into metacells: disjoint and homog...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790056/ https://www.ncbi.nlm.nih.gov/pubmed/31604482 http://dx.doi.org/10.1186/s13059-019-1812-2 |