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Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human‐ and Animal‐Pathogenic Burkholderia Species

Burkholderia species such as B. mallei and B. pseudomallei are bacterial pathogens causing fatal infections in humans and animals (glanders and melioidosis), yet knowledge on their virulence factors is limited. While pathogenic effects have been linked to a highly conserved gene locus (bur/mal) in t...

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Detalles Bibliográficos
Autores principales: Trottmann, Felix, Franke, Jakob, Richter, Ingrid, Ishida, Keishi, Cyrulies, Michael, Dahse, Hans‐Martin, Regestein, Lars, Hertweck, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790655/
https://www.ncbi.nlm.nih.gov/pubmed/31353766
http://dx.doi.org/10.1002/anie.201907324