Selective Modification of Ribosomally Synthesized and Post‐Translationally Modified Peptides (RiPPs) through Diels–Alder Cycloadditions on Dehydroalanine Residues

We report the late‐stage chemical modification of ribosomally synthesized and post‐translationally modified peptides (RIPPs) by Diels–Alder cycloadditions to naturally occurring dehydroalanines. The tail region of the thiopeptide thiostrepton could be modified selectively and efficiently under micro...

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Detalles Bibliográficos
Autores principales: de Vries, Reinder H., Viel, Jakob H., Oudshoorn, Ruben, Kuipers, Oscar P., Roelfes, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790694/
https://www.ncbi.nlm.nih.gov/pubmed/31361053
http://dx.doi.org/10.1002/chem.201902907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790694/
https://www.ncbi.nlm.nih.gov/pubmed/31361053
http://dx.doi.org/10.1002/chem.201902907

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