Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin ( FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads to atopic inflammation remain incompletely u...

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Detalles Bibliográficos
Autores principales: Elias, Martina S., Wright, Sheila C., Nicholson, William V., Morrison, Kimberley D., Prescott, Alan R., Ten Have, Sara, Whitfield, Phillip D., Lamond, Angus I., Brown, Sara J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790913/
https://www.ncbi.nlm.nih.gov/pubmed/31641698
http://dx.doi.org/10.12688/wellcomeopenres.15405.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790913/
https://www.ncbi.nlm.nih.gov/pubmed/31641698
http://dx.doi.org/10.12688/wellcomeopenres.15405.2

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