Cargando…

Toward the Optimization of (+)-[(11)C]PHNO Synthesis: Time Reduction and Process Validation

(+)-[(11)C]PHNO, a dopamine D(2/3) receptor agonistic radiotracer, is applied for investigating the dopaminergic system via positron emission tomography (PET). An improved understanding of neuropsychiatric disorders associated with dysfunctions in the dopamine system and the underlying mechanism is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pfaff, Sarah, Philippe, Cécile, Nics, Lukas, Berroterán-Infante, Neydher, Pallitsch, Katharina, Rami-Mark, Christina, Weidenauer, Ana, Sauerzopf, Ulrich, Willeit, Matthäus, Mitterhauser, Markus, Hacker, Marcus, Wadsak, Wolfgang, Pichler, Verena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791232/ https://www.ncbi.nlm.nih.gov/pubmed/31656452 http://dx.doi.org/10.1155/2019/4292596

Ejemplares similares

PM476. d-Amphetamine-induced sensitization of the dopaminergic system in healthy human subjects: A [(11)C]-(+)-PHNO-PET study
por: Ana, Popovic, et al.
Publicado: (2016)

Association of dopamine D(2/3) receptor binding potential measured using PET and [(11)C]-(+)-PHNO with post-mortem DRD(2/3) gene expression in the human brain
por: Komorowski, Arkadiusz, et al.
Publicado: (2020)

Optimization of the Automated Synthesis of [(11)C]mHED—Administered and Apparent Molar Activities
por: Vraka, Chrysoula, et al.
Publicado: (2019)

Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO()
por: Rami-Mark, Christina, et al.
Publicado: (2013)

On the relationship of first-episode psychosis to the amphetamine-sensitized state: a dopamine D(2/3) receptor agonist radioligand study
por: Weidenauer, Ana, et al.
Publicado: (2020)

Binding Affinity of Some Endogenous and Synthetic TSPO Ligands Regarding the rs6971 Polymorphism
por: Berroterán-Infante, Neydher, et al.
Publicado: (2019)

Radiosynthesis and first preclinical evaluation of the novel norepinephrine transporter pet-ligand [(11)C]ME@HAPTHI
por: Rami-Mark, Christina, et al.
Publicado: (2015)

Comparison of fully-automated radiosyntheses of [(11)C]erlotinib for preclinical and clinical use starting from in target produced [(11)C]CO(2) or [(11)C]CH(4)
por: Philippe, Cécile, et al.
Publicado: (2018)

PM478. Imaging the effects of d-amphetamine in the human brain for modelling dopaminergic alterations in schizophrenia
por: Willeit, Matthäus, et al.
Publicado: (2016)

Disrupted relationship between blood glucose and brain dopamine D2/3 receptor binding in patients with first-episode schizophrenia
por: Sauerzopf, U., et al.
Publicado: (2021)

In vivo evaluation of radiotracers targeting the melanin-concentrating hormone receptor 1: [(11)C]SNAP-7941 and [(18)F]FE@SNAP reveal specific uptake in the ventricular system
por: Zeilinger, Markus, et al.
Publicado: (2017)

SNAPshots of the MCHR1: a Comparison Between the PET-Tracers [(18)F]FE@SNAP and [(11)C]SNAP-7941
por: Philippe, Cécile, et al.
Publicado: (2018)

New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics
por: Zeilinger, Markus, et al.
Publicado: (2017)

Topologically Guided Prioritization of Candidate Gene Transcripts Coexpressed with the 5-HT(1A) Receptor by Combining In Vivo PET and Allen Human Brain Atlas Data
por: Unterholzner, Jakob, et al.
Publicado: (2020)

Preclinical In Vitro and In Vivo Evaluation of [(18)F]FE@SUPPY for Cancer PET Imaging: Limitations of a Xenograft Model for Colorectal Cancer
por: Balber, T., et al.
Publicado: (2018)

Development and evaluation of a rapid analysis for HEPES determination in (68)Ga-radiotracers
por: Pfaff, Sarah, et al.
Publicado: (2018)

Serotonin Transporter Binding in the Human Brain After Pharmacological Challenge Measured Using PET and PET/MR
por: Silberbauer, Leo R., et al.
Publicado: (2019)

On the Road towards Small-Molecule Programmed Cell Death 1 Ligand 1 Positron Emission Tomography Tracers: A Ligand-Based Drug Design Approach
por: Bamminger, Karsten, et al.
Publicado: (2023)

Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo
por: James, Gregory M, et al.
Publicado: (2019)

Simultaneous radiomethylation of [(11)C]harmine and [(11)C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual
por: Vraka, Chrysoula, et al.
Publicado: (2022)

Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials
por: Fazekas-Singer, Judit, et al.
Publicado: (2017)

Sorbitol as a Polar Pharmacological Modifier to Enhance the Hydrophilicity of (99m)Tc-Tricarbonyl-Based Radiopharmaceuticals
por: Giammei, Carolina, et al.
Publicado: (2020)

Are reprogrammed cells a useful tool for studying dopamine dysfunction in psychotic disorders? A review of the current evidence
por: Sauerzopf, Ulrich, et al.
Publicado: (2016)

Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI
por: Rischka, Lucas, et al.
Publicado: (2019)

Making Sense of: Sensitization in Schizophrenia
por: Weidenauer, Ana, et al.
Publicado: (2016)

Assessment of Ketamine Binding of the Serotonin Transporter in Humans with Positron Emission Tomography
por: Spies, Marie, et al.
Publicado: (2017)

Pitfalls and solutions of the fully-automated radiosynthesis of [(11)C]metoclopramide
por: Pichler, Verena, et al.
Publicado: (2019)

Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[(11)C]Me-NB1
por: Rischka, Lucas, et al.
Publicado: (2022)

Influence of Nicotine Metabolism Ratio on [(11)C]-(+)-PHNO PET Binding in Tobacco Smokers
por: Di Ciano, Patricia, et al.
Publicado: (2018)

[(18)F]FMeNER-D2: Reliable fully-automated synthesis for visualization of the norepinephrine transporter
por: Rami-Mark, Christina, et al.
Publicado: (2013)

**-Postprandial pancreatic [(11)C]methionine uptake after pancreaticoduodenectomy mirrors basal beta cell function and insulin release
por: Steiner, Emanuel, et al.
Publicado: (2016)

Preparation and First Preclinical Evaluation of [(18)F]FE@SNAP: A Potential PET Tracer for the Melanin-Concentrating Hormone Receptor-1 (MCHR1)
por: Philippe, Cécile, et al.
Publicado: (2013)

In vitro Radiopharmaceutical Evidence for MCHR1 Binding Sites in Murine Brown Adipocytes
por: Balber, Theresa, et al.
Publicado: (2019)

Evaluation of dopamine D(3) receptor occupancy by blonanserin using [(11)C]-(+)-PHNO in schizophrenia patients
por: Sakayori, Takeshi, et al.
Publicado: (2020)

Dynamic [18F]FET-PET/MRI using standard MRI-based attenuation correction methods
por: Rausch, Ivo, et al.
Publicado: (2019)

Prospective validation of 18F-Fluoroethylcholine as a tracer in PET/MRI for the evaluation of breast lesions and prediction of lymph node status
por: Clauser, Paola, et al.
Publicado: (2023)

Parameter evaluation and fully-automated radiosynthesis of [(11)C]harmine for imaging of MAO-A for clinical trials
por: Philippe, C., et al.
Publicado: (2015)

[(18)F]FE@SUPPY: a suitable PET tracer for the adenosine A3 receptor? An in vivo study in rodents
por: Haeusler, Daniela, et al.
Publicado: (2015)

[(11)C]acetate PET as a tool for diagnosis of liver steatosis
por: Nejabat, Marzieh, et al.
Publicado: (2018)

Effect of MAOA DNA Methylation on Human in Vivo Protein Expression Measured by [(11)C]harmine Positron Emission Tomography
por: Handschuh, Patricia A, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_oj3ej8mc4jssv4o9s5a62v01st