GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways

GCN5, the catalytic subunit in the acetyltransferase modules of SAGA and ATAC, functions as a coactivator of gene transcription. The SAGA complex is recruited to chromatin by transcription factors such as MYC and E2F1 to facilitate acetylation of histones, especially H3 at lysine 9 (H3K9). Burkitt l...

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Detalles Bibliográficos
Autores principales: Farria, Aimee T., Mustachio, Lisa Maria, Akdemir, Zeynep H. Coban, Dent, Sharon Y.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791378/
https://www.ncbi.nlm.nih.gov/pubmed/31645904
http://dx.doi.org/10.18632/oncotarget.27226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791378/
https://www.ncbi.nlm.nih.gov/pubmed/31645904
http://dx.doi.org/10.18632/oncotarget.27226

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