CD80 expression promotes immune surveillance in Barrett’s metaplasia
Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell efficacy. Here we report for the first time the rol...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791427/ https://www.ncbi.nlm.nih.gov/pubmed/31646078 http://dx.doi.org/10.1080/2162402X.2019.1636618 |
_version_ | 1783458978747908096 |
---|---|
author | Scarpa, Melania Fassan, Matteo Kotsafti, Andromachi Realdon, Stefano Dall’Olmo, Luigi Morbin, Tiziana Cavallin, Francesco Saadeh, Luca Cagol, Matteo Alfieri, Rita Castoro, Carlo Rugge, Massimo Castagliuolo, Ignazio Scarpa, Marco |
author_facet | Scarpa, Melania Fassan, Matteo Kotsafti, Andromachi Realdon, Stefano Dall’Olmo, Luigi Morbin, Tiziana Cavallin, Francesco Saadeh, Luca Cagol, Matteo Alfieri, Rita Castoro, Carlo Rugge, Massimo Castagliuolo, Ignazio Scarpa, Marco |
author_sort | Scarpa, Melania |
collection | PubMed |
description | Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell efficacy. Here we report for the first time the role of CD80 in the inflammatory esophageal carcinogenesis and characterize the immune environment of EAC. Mucosa samples from cancer were obtained during esophagectomy from patients affected by EAC. Fresh biopsies were obtained from patients who underwent endoscopy for screening or follow-up. A rodent model of reflux induced esophageal carcinogenesis was created with an esophago-gastro-jejunostomy. CD80 expression was increased in epithelial cells during metaplasia in the inflammatory esophageal carcinogenesis cascade. Cd80 null mice as well as WT mice that received antiCD80 antibodies showed a higher rate of dysplasia and KI-67+ cells. These results suggest that CD80 mediates an active immune surveillance process in early inflammation-driven esophageal carcinogenesis. |
format | Online Article Text |
id | pubmed-6791427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-67914272019-10-23 CD80 expression promotes immune surveillance in Barrett’s metaplasia Scarpa, Melania Fassan, Matteo Kotsafti, Andromachi Realdon, Stefano Dall’Olmo, Luigi Morbin, Tiziana Cavallin, Francesco Saadeh, Luca Cagol, Matteo Alfieri, Rita Castoro, Carlo Rugge, Massimo Castagliuolo, Ignazio Scarpa, Marco Oncoimmunology Brief Report Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell efficacy. Here we report for the first time the role of CD80 in the inflammatory esophageal carcinogenesis and characterize the immune environment of EAC. Mucosa samples from cancer were obtained during esophagectomy from patients affected by EAC. Fresh biopsies were obtained from patients who underwent endoscopy for screening or follow-up. A rodent model of reflux induced esophageal carcinogenesis was created with an esophago-gastro-jejunostomy. CD80 expression was increased in epithelial cells during metaplasia in the inflammatory esophageal carcinogenesis cascade. Cd80 null mice as well as WT mice that received antiCD80 antibodies showed a higher rate of dysplasia and KI-67+ cells. These results suggest that CD80 mediates an active immune surveillance process in early inflammation-driven esophageal carcinogenesis. Taylor & Francis 2019-07-23 /pmc/articles/PMC6791427/ /pubmed/31646078 http://dx.doi.org/10.1080/2162402X.2019.1636618 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Brief Report Scarpa, Melania Fassan, Matteo Kotsafti, Andromachi Realdon, Stefano Dall’Olmo, Luigi Morbin, Tiziana Cavallin, Francesco Saadeh, Luca Cagol, Matteo Alfieri, Rita Castoro, Carlo Rugge, Massimo Castagliuolo, Ignazio Scarpa, Marco CD80 expression promotes immune surveillance in Barrett’s metaplasia |
title | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
title_full | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
title_fullStr | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
title_full_unstemmed | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
title_short | CD80 expression promotes immune surveillance in Barrett’s metaplasia |
title_sort | cd80 expression promotes immune surveillance in barrett’s metaplasia |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791427/ https://www.ncbi.nlm.nih.gov/pubmed/31646078 http://dx.doi.org/10.1080/2162402X.2019.1636618 |
work_keys_str_mv | AT scarpamelania cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT fassanmatteo cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT kotsaftiandromachi cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT realdonstefano cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT dallolmoluigi cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT morbintiziana cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT cavallinfrancesco cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT saadehluca cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT cagolmatteo cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT alfieririta cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT castorocarlo cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT ruggemassimo cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT castagliuoloignazio cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia AT scarpamarco cd80expressionpromotesimmunesurveillanceinbarrettsmetaplasia |