CD80 expression promotes immune surveillance in Barrett’s metaplasia

Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell efficacy. Here we report for the first time the rol...

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Autores principales: Scarpa, Melania, Fassan, Matteo, Kotsafti, Andromachi, Realdon, Stefano, Dall’Olmo, Luigi, Morbin, Tiziana, Cavallin, Francesco, Saadeh, Luca, Cagol, Matteo, Alfieri, Rita, Castoro, Carlo, Rugge, Massimo, Castagliuolo, Ignazio, Scarpa, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791427/
https://www.ncbi.nlm.nih.gov/pubmed/31646078
http://dx.doi.org/10.1080/2162402X.2019.1636618
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author Scarpa, Melania
Fassan, Matteo
Kotsafti, Andromachi
Realdon, Stefano
Dall’Olmo, Luigi
Morbin, Tiziana
Cavallin, Francesco
Saadeh, Luca
Cagol, Matteo
Alfieri, Rita
Castoro, Carlo
Rugge, Massimo
Castagliuolo, Ignazio
Scarpa, Marco
author_facet Scarpa, Melania
Fassan, Matteo
Kotsafti, Andromachi
Realdon, Stefano
Dall’Olmo, Luigi
Morbin, Tiziana
Cavallin, Francesco
Saadeh, Luca
Cagol, Matteo
Alfieri, Rita
Castoro, Carlo
Rugge, Massimo
Castagliuolo, Ignazio
Scarpa, Marco
author_sort Scarpa, Melania
collection PubMed
description Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell efficacy. Here we report for the first time the role of CD80 in the inflammatory esophageal carcinogenesis and characterize the immune environment of EAC. Mucosa samples from cancer were obtained during esophagectomy from patients affected by EAC. Fresh biopsies were obtained from patients who underwent endoscopy for screening or follow-up. A rodent model of reflux induced esophageal carcinogenesis was created with an esophago-gastro-jejunostomy. CD80 expression was increased in epithelial cells during metaplasia in the inflammatory esophageal carcinogenesis cascade. Cd80 null mice as well as WT mice that received antiCD80 antibodies showed a higher rate of dysplasia and KI-67+ cells. These results suggest that CD80 mediates an active immune surveillance process in early inflammation-driven esophageal carcinogenesis.
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spelling pubmed-67914272019-10-23 CD80 expression promotes immune surveillance in Barrett’s metaplasia Scarpa, Melania Fassan, Matteo Kotsafti, Andromachi Realdon, Stefano Dall’Olmo, Luigi Morbin, Tiziana Cavallin, Francesco Saadeh, Luca Cagol, Matteo Alfieri, Rita Castoro, Carlo Rugge, Massimo Castagliuolo, Ignazio Scarpa, Marco Oncoimmunology Brief Report Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell efficacy. Here we report for the first time the role of CD80 in the inflammatory esophageal carcinogenesis and characterize the immune environment of EAC. Mucosa samples from cancer were obtained during esophagectomy from patients affected by EAC. Fresh biopsies were obtained from patients who underwent endoscopy for screening or follow-up. A rodent model of reflux induced esophageal carcinogenesis was created with an esophago-gastro-jejunostomy. CD80 expression was increased in epithelial cells during metaplasia in the inflammatory esophageal carcinogenesis cascade. Cd80 null mice as well as WT mice that received antiCD80 antibodies showed a higher rate of dysplasia and KI-67+ cells. These results suggest that CD80 mediates an active immune surveillance process in early inflammation-driven esophageal carcinogenesis. Taylor & Francis 2019-07-23 /pmc/articles/PMC6791427/ /pubmed/31646078 http://dx.doi.org/10.1080/2162402X.2019.1636618 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Brief Report
Scarpa, Melania
Fassan, Matteo
Kotsafti, Andromachi
Realdon, Stefano
Dall’Olmo, Luigi
Morbin, Tiziana
Cavallin, Francesco
Saadeh, Luca
Cagol, Matteo
Alfieri, Rita
Castoro, Carlo
Rugge, Massimo
Castagliuolo, Ignazio
Scarpa, Marco
CD80 expression promotes immune surveillance in Barrett’s metaplasia
title CD80 expression promotes immune surveillance in Barrett’s metaplasia
title_full CD80 expression promotes immune surveillance in Barrett’s metaplasia
title_fullStr CD80 expression promotes immune surveillance in Barrett’s metaplasia
title_full_unstemmed CD80 expression promotes immune surveillance in Barrett’s metaplasia
title_short CD80 expression promotes immune surveillance in Barrett’s metaplasia
title_sort cd80 expression promotes immune surveillance in barrett’s metaplasia
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791427/
https://www.ncbi.nlm.nih.gov/pubmed/31646078
http://dx.doi.org/10.1080/2162402X.2019.1636618
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