Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy

Previous studies have demonstrated intrarenal hypoxia in patients with diabetes. Hypoxia-inducible factor (HIF)-1 plays an important role in hypoxia-induced tubulointerstitial fibrosis. Recent clinical trials have confirmed the renoprotective action of SGLT2 inhibitors in diabetic nephropathy. We ex...

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Detalles Bibliográficos
Autores principales: Bessho, Ryoichi, Takiyama, Yumi, Takiyama, Takao, Kitsunai, Hiroya, Takeda, Yasutaka, Sakagami, Hidemitsu, Ota, Tsuguhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791873/
https://www.ncbi.nlm.nih.gov/pubmed/31611596
http://dx.doi.org/10.1038/s41598-019-51343-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791873/
https://www.ncbi.nlm.nih.gov/pubmed/31611596
http://dx.doi.org/10.1038/s41598-019-51343-1

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