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Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy

Previous studies have demonstrated intrarenal hypoxia in patients with diabetes. Hypoxia-inducible factor (HIF)-1 plays an important role in hypoxia-induced tubulointerstitial fibrosis. Recent clinical trials have confirmed the renoprotective action of SGLT2 inhibitors in diabetic nephropathy. We ex...

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Detalles Bibliográficos
Autores principales:	Bessho, Ryoichi, Takiyama, Yumi, Takiyama, Takao, Kitsunai, Hiroya, Takeda, Yasutaka, Sakagami, Hidemitsu, Ota, Tsuguhito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791873/ https://www.ncbi.nlm.nih.gov/pubmed/31611596 http://dx.doi.org/10.1038/s41598-019-51343-1

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