Evaluation of integrin αvβ(6) cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis

Advances in precision molecular imaging promise to transform our ability to detect, diagnose and treat disease. Here, we describe the engineering and validation of a new cystine knot peptide (knottin) that selectively recognizes human integrin αvβ(6) with single-digit nanomolar affinity. We solve it...

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Detalles Bibliográficos
Autores principales: Kimura, Richard H., Wang, Ling, Shen, Bin, Huo, Li, Tummers, Willemieke, Filipp, Fabian V., Guo, Haiwei Henry, Haywood, Thomas, Abou-Elkacem, Lotfi, Baratto, Lucia, Habte, Frezghi, Devulapally, Rammohan, Witney, Timothy H., Cheng, Yan, Tikole, Suhas, Chakraborti, Subhendu, Nix, Jay, Bonagura, Christopher A., Hatami, Negin, Mooney, Joshua J., Desai, Tushar, Turner, Scott, Gaster, Richard S., Otte, Andrea, Visser, Brendan C., Poultsides, George A., Norton, Jeffrey, Park, Walter, Stolowitz, Mark, Lau, Kenneth, Yang, Eric, Natarajan, Arutselvan, Ilovich, Ohad, Srinivas, Shyam, Srinivasan, Ananth, Paulmurugan, Ramasamy, Willmann, Juergen, Chin, Frederick T., Cheng, Zhen, Iagaru, Andrei, Li, Fang, Gambhir, Sanjiv S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791878/
https://www.ncbi.nlm.nih.gov/pubmed/31611594
http://dx.doi.org/10.1038/s41467-019-11863-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791878/
https://www.ncbi.nlm.nih.gov/pubmed/31611594
http://dx.doi.org/10.1038/s41467-019-11863-w

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