Targeting the COX2/MET/TOPK signaling axis induces apoptosis in gefitinib-resistant NSCLC cells

MET overactivation is one of the crucial reasons for tyrosine kinase inhibitor (TKI) resistance, but the mechanisms are not wholly clear. Here, COX2, TOPK, and MET expression were examined in EGFR-activating mutated NSCLC by immunohistochemical (IHC) analysis. The relationship between COX2, TOPK, an...

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Detalles Bibliográficos
Autores principales: Xiao, Juanjuan, Wang, Fei, Lu, Hui, Xu, Sanpeng, Zou, Ling, Tian, Qin, Fu, Yang, Lin, Xuan, Liu, Lin, Yuan, Ping, Ni, Xiaofang, Ma, Tengfei, Zeng, Fanfan, Xue, Peipei, Xiu, Ruijuan, Zhang, Jianmin, Ji, Xinying, Hu, Hongbo, Lu, Shangyun, Dai, Hongtian, Li, Yuan, Chu, Qian, Zhao, Xia, Duan, Qiuhong, Zhu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791885/
https://www.ncbi.nlm.nih.gov/pubmed/31611604
http://dx.doi.org/10.1038/s41419-019-2020-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791885/
https://www.ncbi.nlm.nih.gov/pubmed/31611604
http://dx.doi.org/10.1038/s41419-019-2020-4

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