Spectrum of TERT promoter mutations and mechanisms of activation in thyroid cancer

BACKGROUND: Reactivation of telomerase reverse transcriptase (TERT) is an important event in cancer. Two hotspot mutations in the TERT promoter region, c.‐124C > T (C228T) and c.‐146C > T (C250T), occur in various cancer types including thyroid cancer. They generate de novo binding sites for E...

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Detalles Bibliográficos
Autores principales: Panebianco, Federica, Nikitski, Alyaksandr V., Nikiforova, Marina N., Nikiforov, Yuri E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792496/
https://www.ncbi.nlm.nih.gov/pubmed/31408918
http://dx.doi.org/10.1002/cam4.2467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792496/
https://www.ncbi.nlm.nih.gov/pubmed/31408918
http://dx.doi.org/10.1002/cam4.2467

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