Cargando…

Spectrum of TERT promoter mutations and mechanisms of activation in thyroid cancer

BACKGROUND: Reactivation of telomerase reverse transcriptase (TERT) is an important event in cancer. Two hotspot mutations in the TERT promoter region, c.‐124C > T (C228T) and c.‐146C > T (C250T), occur in various cancer types including thyroid cancer. They generate de novo binding sites for E...

Descripción completa

Detalles Bibliográficos
Autores principales:	Panebianco, Federica, Nikitski, Alyaksandr V., Nikiforova, Marina N., Nikiforov, Yuri E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Clinical Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792496/ https://www.ncbi.nlm.nih.gov/pubmed/31408918 http://dx.doi.org/10.1002/cam4.2467

Ejemplares similares

OR21-02 Impact of Nodule Size on the Probability of Hurthle Cell Carcinoma and Other Cancers in Thyroid Nodules with Multiple Chromosomal Copy Number Alterations
por: Nikiforova, Marina N, et al.
Publicado: (2020)

Performance of a Multigene Genomic Classifier in Thyroid Nodules with Suspicious for Malignancy Cytology
por: Skaugen, John M., et al.
Publicado: (2022)

Risk assessment for distant metastasis in differentiated thyroid cancer using molecular profiling: A matched case‐control study
por: Yip, Linwah, et al.
Publicado: (2021)

Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements
por: Evdokimova, Viktoria N., et al.
Publicado: (2018)

Clinicopathologic Characteristics of Thyroid Nodules Positive for PTEN Mutations on Preoperative Molecular Testing
por: Quaytman, Jacob, et al.
Publicado: (2021)

Human TERT promoter mutations as a prognostic biomarker in glioma
por: Powter, Branka, et al.
Publicado: (2021)

The TERT promoter mutation status and MGMT promoter methylation status, combined with dichotomized MRI‐derived and clinical features, predict adult primary glioblastoma survival
por: Shu, Chang, et al.
Publicado: (2018)

TERT promoter mutations and monoallelic activation of TERT in cancer
por: Huang, F W, et al.
Publicado: (2015)

THYROID CARCINOMA-ASSOCIATED GENETIC MUTATIONS ALSO OCCUR IN THYROID LYMPHOMAS
por: Aggarwal, Nidhi, et al.
Publicado: (2012)

MON-570 Clinical Utility of ThyroSeq v3 Genomic Classifier Test in Detecting Gene Fusions in Thyroid Nodules
por: Nikiforova, Marina, et al.
Publicado: (2019)

TERT mutations correlate with higher TMB value and unique tumor microenvironment and may be a potential biomarker for anti‐CTLA4 treatment
por: Li, Huahua, et al.
Publicado: (2020)

TERT Immunohistochemistry Is a Poor Predictor of TERT Promoter Mutations and Gene Expression in Follicular Thyroid Carcinoma
por: Paulsson, Johan O., et al.
Publicado: (2018)

TERT Promoter Mutations and Tumor Persistence/Recurrence in Papillary Thyroid Cancer
por: Myung, Jae Kyung, et al.
Publicado: (2016)

Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations
por: Park, Hyunju, et al.
Publicado: (2021)

Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology
por: Nikiforov, Yuri E., et al.
Publicado: (2015)

Limitations of Detecting Genetic Variants from the RNA Sequencing Data in Tissue and Fine-Needle Aspiration Samples
por: Kaya, Cihan, et al.
Publicado: (2021)

TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma
por: Mosrati, Mohamed Ali, et al.
Publicado: (2015)

Low Prevalence of Somatic TERT Promoter Mutations in Classic Papillary Thyroid Carcinoma
por: Jeon, Min Ji, et al.
Publicado: (2016)

Ultrasound and clinicopathological features of papillary thyroid carcinomas with BRAF and TERT promoter mutations
por: Hahn, Soo Yeon, et al.
Publicado: (2017)

The role of TERT promoter mutations in postoperative and preoperative diagnosis and prognosis in thyroid cancer
por: Jin, Anqi, et al.
Publicado: (2018)

TERT Promoter Mutations and Their Impact on Gene Expression Profile in Papillary Thyroid Carcinoma
por: Rusinek, Dagmara, et al.
Publicado: (2020)

TERT promoter mutations and telomere length in adult malignant gliomas and recurrences
por: Heidenreich, Barbara, et al.
Publicado: (2015)

TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation
por: Vallarelli, Andrelou F., et al.
Publicado: (2016)

Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers
por: Stern, Josh Lewis, et al.
Publicado: (2015)

Papillary Thyroid Cancer and a TERT Promotor Mutation-positive Paraganglioma in a Patient With a Germline SDHB Mutation
por: Alzahrani, Ali S, et al.
Publicado: (2022)

TERT Promoter Mutations Increase Sense and Antisense Transcription from the TERT Promoter
por: Hafezi, François, et al.
Publicado: (2021)

OR32-06 Disease-related Outcomes In Patients With Thyroid Cancer On Long Term Follow-up: Analysis Of 1487 Patients
por: Doerfler, William R, et al.
Publicado: (2023)

TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas
por: Melo, Miguel, et al.
Publicado: (2014)

Advances in Detecting Low Prevalence Somatic TERT Promoter Mutations in Papillary Thyroid Carcinoma
por: da Costa, Vitor Rodrigues, et al.
Publicado: (2021)

Prospective Analysis of TERT Promoter Mutations in Papillary Thyroid Carcinoma at a Single Institution
por: Choi, Yun-Suk, et al.
Publicado: (2021)

Proposal of a New Prognostic Model for Differentiated Thyroid Cancer with TERT Promoter Mutations
por: Park, Jun, et al.
Publicado: (2021)

Effect of Having Concurrent Mutations on the Degree of Aggressiveness in Patients with Thyroid Cancer Positive for TERT Promoter Mutations
por: Alohali, Sama, et al.
Publicado: (2023)

Preoperative detection of TERT promoter and BRAF(V600E) mutations in papillary thyroid carcinoma in high-risk thyroid nodules
por: Giorgenon, Tatiana Marina Vieira, et al.
Publicado: (2019)

TERT promoter mutations and gene amplification: Promoting TERT expression in Merkel cell carcinoma
por: Xie, Hong, et al.
Publicado: (2014)

TERT promoter mutations in melanoma survival
por: Nagore, Eduardo, et al.
Publicado: (2019)

The Solo Play of TERT Promoter Mutations
por: Hafezi, François, et al.
Publicado: (2020)

TERT Promoter Mutations and Telomerase in Melanoma
por: Guo, Yuchen, et al.
Publicado: (2022)

TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases
por: Insilla, Andrea Cacciato, et al.
Publicado: (2018)

BRAF V600E and TERT Promoter Mutations in Papillary Thyroid Carcinoma in Chinese Patients
por: Sun, Jian, et al.
Publicado: (2016)

BRAF and TERT promoter mutations in the aggressiveness of papillary thyroid carcinoma: a study of 653 patients
por: Jin, Langping, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ctfd2lmmfof8hjdb4mvdae9oj1