Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity

Tau is a highly soluble microtubule-associated protein that acts within neurons to modify microtubule stability. However, abnormally phosphorylated tau dissociates from microtubules to form oligomers and fibrils which associate in the somatodendritic compartment. Although tau can form neurofibrillar...

Descripción completa

Detalles Bibliográficos
Autores principales: Hill, Emily, Karikari, Thomas K., Moffat, Kevin G., Richardson, Magnus J. E., Wall, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794083/
https://www.ncbi.nlm.nih.gov/pubmed/31554666
http://dx.doi.org/10.1523/ENEURO.0166-19.2019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794083/
https://www.ncbi.nlm.nih.gov/pubmed/31554666
http://dx.doi.org/10.1523/ENEURO.0166-19.2019

Ejemplares similares