Cargando…

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum

To further our understanding of one-carbon metabolism in the protozoan parasite Leishmania, we conducted genomic screens to study how the parasite responded to sinefungin (SNF) selection. SNF is a structural analogue of S-adenosylmethionine (AdoMet), a key methyl group donor to a number of biomolecu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhattacharya, Arijit, Sharma, Mansi, Pakkinathan, Charles, Rosen, Barry P., Leprohon, Philippe, Ouellette, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794121/ https://www.ncbi.nlm.nih.gov/pubmed/31615876 http://dx.doi.org/10.1128/mSystems.00416-19

Ejemplares similares

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

Sinefungin, a Natural Nucleoside Analogue of S-Adenosylmethionine, Inhibits Streptococcus pneumoniae Biofilm Growth
por: Yadav, Mukesh Kumar, et al.
Publicado: (2014)

New insights with miltefosine unresponsiveness in Brazilian Leishmania infantum isolates
por: Bhattacharya, Arijit, et al.
Publicado: (2018)

MRPA-independent mechanisms of antimony resistance in Leishmania infantum
por: Douanne, Noélie, et al.
Publicado: (2020)

Thiophene derivatives activity against the protozoan parasite Leishmania infantum
por: Bigot, Sophia, et al.
Publicado: (2022)

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms
por: Fernandez-Prada, Christopher, et al.
Publicado: (2018)

Decreased glutamate transport in acivicin resistant Leishmania tarentolae
por: Roy, Gaétan, et al.
Publicado: (2021)

Proteomic and Genomic Analyses of Antimony Resistant Leishmania infantum Mutant
por: Brotherton, Marie-Christine, et al.
Publicado: (2013)

Gene Amplification and Point Mutations in Pyrimidine Metabolic Genes in 5-Fluorouracil Resistant Leishmania infantum
por: Ritt, Jean-François, et al.
Publicado: (2013)

Increased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum()
por: Potvin, Jade-Éva, et al.
Publicado: (2023)

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum
por: Leprohon, Philippe, et al.
Publicado: (2009)

Analogues of the natural product Sinefungin as potent inhibitors of EHMT1 and EHMT2
por: Devkota, Kanchan, et al.
Publicado: (2013)

New insights in the mode of action of anti-leishmanial drugs by using chemical mutagenesis screens coupled to next-generation sequencing
por: Bhattacharya, Arijit, et al.
Publicado: (2020)

Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania
por: Bhattacharya, Arijit, et al.
Publicado: (2019)

Generation of Leishmania Hybrids by Whole Genomic DNA Transformation
por: Coelho, Adriano C., et al.
Publicado: (2012)

Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum
por: Vincent, Isabel M., et al.
Publicado: (2015)

Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism()
por: Vincent, Isabel M., et al.
Publicado: (2013)

Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection
por: Bigot, Sophia, et al.
Publicado: (2023)

Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy number
por: Yasur-Landau, Daniel, et al.
Publicado: (2018)

Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan
por: Rosa-Teijeiro, Chloé, et al.
Publicado: (2021)

Deciphering the mechanism of action of VP343, an antileishmanial drug candidate, in Leishmania infantum
por: Obeid, Sameh, et al.
Publicado: (2023)

Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum
por: Brotherton, Marie-Christine, et al.
Publicado: (2014)

Drug resistance analysis by next generation sequencing in Leishmania
por: Leprohon, Philippe, et al.
Publicado: (2014)

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance
por: Laffitte, Marie-Claude N., et al.
Publicado: (2016)

Troubleshooting Real-Time PCR Screening for Leishmania infantum
por: de Mendonça, Philippe Gil
Publicado: (2018)

Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania
por: Moreira, W, et al.
Publicado: (2011)

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2015)

Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analogues
por: Joce, Catherine, et al.
Publicado: (2012)

A Multiplatform Metabolomic Approach to the Basis of Antimonial Action and Resistance in Leishmania infantum
por: Rojo, David, et al.
Publicado: (2015)

New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C(8) Substitution in Structural Analogues of S-Adenosylmethionine
por: McCloskey, Diane E., et al.
Publicado: (2009)

Leishmania infantum in US-Born Dog
por: de Almeida, Marcos E., et al.
Publicado: (2020)

Vaccination with Leishmania infantum Acidic Ribosomal P0 but Not with Nucleosomal Histones Proteins Controls Leishmania infantum Infection in Hamsters
por: Pereira, Lais, et al.
Publicado: (2015)

Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species
por: Rochette, Annie, et al.
Publicado: (2008)

Leishmaniasis in Northern Morocco: Predominance of Leishmania infantum Compared to Leishmania tropica
por: Hakkour, Maryam, et al.
Publicado: (2019)

Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB
por: Pérez-Pertejo, Yolanda, et al.
Publicado: (2019)

Leishmania tropica and Leishmania infantum infection in dogs and cats in central Israel
por: Baneth, Gad, et al.
Publicado: (2022)

Oral and Intragastric: New Routes of Infection by Leishmania braziliensis and Leishmania infantum?
por: Reimann, Mayra M., et al.
Publicado: (2022)

Leishmania infantum leishmaniasis in corticosteroid – treated patients
por: Pittalis, Silvia, et al.
Publicado: (2006)

Manifestations of paediatric Leishmania infantum infections in Malta
por: Pace, David, et al.
Publicado: (2011)

Leishmania infantum and Human Visceral Leishmaniasis, Argentina
por: Barrio, Alejandra, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qojnasjmj4nmtntsca8tkcn812