Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism

Human primary aldosteronism (PA) can be caused by mutations in several ion channel genes but mouse models replicating this condition are lacking. We now show that almost all known PA-associated CLCN2 mutations markedly increase ClC-2 chloride currents and generate knock-in mice expressing a constitu...

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Detalles Bibliográficos
Autores principales: Göppner, Corinna, Orozco, Ian J., Hoegg-Beiler, Maja B., Soria, Audrey H., Hübner, Christian A., Fernandes-Rosa, Fabio L., Boulkroun, Sheerazed, Zennaro, Maria-Christina, Jentsch, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794291/
https://www.ncbi.nlm.nih.gov/pubmed/31615979
http://dx.doi.org/10.1038/s41467-019-12113-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794291/
https://www.ncbi.nlm.nih.gov/pubmed/31615979
http://dx.doi.org/10.1038/s41467-019-12113-9

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