Cargando…
Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism
Human primary aldosteronism (PA) can be caused by mutations in several ion channel genes but mouse models replicating this condition are lacking. We now show that almost all known PA-associated CLCN2 mutations markedly increase ClC-2 chloride currents and generate knock-in mice expressing a constitu...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794291/ https://www.ncbi.nlm.nih.gov/pubmed/31615979 http://dx.doi.org/10.1038/s41467-019-12113-9 |