Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC

Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). However, the development of drug resistance is common. By using genome-wide CRISPR/Cas9 library screening, we identify phosphoglycerate dehydrogenase (PHGDH), the first committed enzyme in the serine synthesis pathway (...

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Detalles Bibliográficos
Autores principales: Wei, Lai, Lee, Derek, Law, Cheuk-Ting, Zhang, Misty Shuo, Shen, Jialing, Chin, Don Wai-Ching, Zhang, Allen, Tsang, Felice Ho-Ching, Wong, Ceci Lok-Sze, Ng, Irene Oi-Lin, Wong, Carmen Chak-Lui, Wong, Chun-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794322/
https://www.ncbi.nlm.nih.gov/pubmed/31615983
http://dx.doi.org/10.1038/s41467-019-12606-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794322/
https://www.ncbi.nlm.nih.gov/pubmed/31615983
http://dx.doi.org/10.1038/s41467-019-12606-7

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