Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation

Locus coeruleus (LC) provides the sole source of noradrenergic (NA) innervation to hippocampus, and it undergoes significant degeneration early in Alzheimer’s disease (AD). Norepinephrine (NE) modulates synaptic transmission and plasticity at hippocampal synapses which likely contributes to hippocam...

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Detalles Bibliográficos
Autores principales: Dyer-Reaves, Katie, Goodman, Anthoni M., Nelson, Amy R., McMahon, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794465/
https://www.ncbi.nlm.nih.gov/pubmed/31649525
http://dx.doi.org/10.3389/fnsyn.2019.00027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794465/
https://www.ncbi.nlm.nih.gov/pubmed/31649525
http://dx.doi.org/10.3389/fnsyn.2019.00027

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