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Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both

BACKGROUND: Transcription factor Nrf2 (nuclear factor-erythroid 2-related factor 2) plays a key role in detoxification of electrophiles via formation of glutathione (GSH) adducts and subsequent excretion into extracellular spaces. We found that reactive sulfur species (RSS), such as cysteine persulf...

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Detalles Bibliográficos
Autores principales:	Akiyama, Masahiro, Unoki, Takamitsu, Shinkai, Yasuhiro, Ishii, Isao, Ida, Tomoaki, Akaike, Takaaki, Yamamoto, Masayuki, Kumagai, Yoshito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Environmental Health Perspectives 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794492/ https://www.ncbi.nlm.nih.gov/pubmed/31166132 http://dx.doi.org/10.1289/EHP4949

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