Synthesis and Enzymatic Incorporation of a Responsive Ribonucleoside Probe That Enables Quantitative Detection of Metallo-Base Pairs

[Image: see text] Synthesis of a highly responsive fluorescent ribonucleoside analogue based on a 5-methoxybenzofuran uracil core, enzymatic incorporation of its triphosphate substrate into RNA transcripts, and its utility in the specific detection and estimation of Hg(2+)-ion-mediated metallo-base...

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Autores principales: Manna, Sudeshna, Srivatsan, Seergazhi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794643/
https://www.ncbi.nlm.nih.gov/pubmed/31184159
http://dx.doi.org/10.1021/acs.orglett.9b01544
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author Manna, Sudeshna
Srivatsan, Seergazhi G.
author_facet Manna, Sudeshna
Srivatsan, Seergazhi G.
author_sort Manna, Sudeshna
collection PubMed
description [Image: see text] Synthesis of a highly responsive fluorescent ribonucleoside analogue based on a 5-methoxybenzofuran uracil core, enzymatic incorporation of its triphosphate substrate into RNA transcripts, and its utility in the specific detection and estimation of Hg(2+)-ion-mediated metallo-base pair formation in DNA–RNA and RNA–RNA duplexes are described.
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spelling pubmed-67946432019-10-17 Synthesis and Enzymatic Incorporation of a Responsive Ribonucleoside Probe That Enables Quantitative Detection of Metallo-Base Pairs Manna, Sudeshna Srivatsan, Seergazhi G. Org Lett [Image: see text] Synthesis of a highly responsive fluorescent ribonucleoside analogue based on a 5-methoxybenzofuran uracil core, enzymatic incorporation of its triphosphate substrate into RNA transcripts, and its utility in the specific detection and estimation of Hg(2+)-ion-mediated metallo-base pair formation in DNA–RNA and RNA–RNA duplexes are described. American Chemical Society 2019-06-07 2019-06-21 /pmc/articles/PMC6794643/ /pubmed/31184159 http://dx.doi.org/10.1021/acs.orglett.9b01544 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Manna, Sudeshna
Srivatsan, Seergazhi G.
Synthesis and Enzymatic Incorporation of a Responsive Ribonucleoside Probe That Enables Quantitative Detection of Metallo-Base Pairs
title Synthesis and Enzymatic Incorporation of a Responsive Ribonucleoside Probe That Enables Quantitative Detection of Metallo-Base Pairs
title_full Synthesis and Enzymatic Incorporation of a Responsive Ribonucleoside Probe That Enables Quantitative Detection of Metallo-Base Pairs
title_fullStr Synthesis and Enzymatic Incorporation of a Responsive Ribonucleoside Probe That Enables Quantitative Detection of Metallo-Base Pairs
title_full_unstemmed Synthesis and Enzymatic Incorporation of a Responsive Ribonucleoside Probe That Enables Quantitative Detection of Metallo-Base Pairs
title_short Synthesis and Enzymatic Incorporation of a Responsive Ribonucleoside Probe That Enables Quantitative Detection of Metallo-Base Pairs
title_sort synthesis and enzymatic incorporation of a responsive ribonucleoside probe that enables quantitative detection of metallo-base pairs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794643/
https://www.ncbi.nlm.nih.gov/pubmed/31184159
http://dx.doi.org/10.1021/acs.orglett.9b01544
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