Cargando…

Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling

Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both in vitro and in vivo during in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Fanhua, Jiang, Zhimin, Sun, Honglei, Pu, Juan, Sun, Yipeng, Wang, Mingyang, Tong, Qi, Bi, Yuhai, Ma, Xiaojing, Gao, George Fu, Liu, Jinhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795447/ https://www.ncbi.nlm.nih.gov/pubmed/31585000 http://dx.doi.org/10.1371/journal.ppat.1008062

Ejemplares similares

Correction: Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
por: Wei, Fanhua, et al.
Publicado: (2020)

Identification of swine influenza A virus and Stenotrophomonas maltophilia co-infection in Chinese pigs
por: Hou, Dongjun, et al.
Publicado: (2012)

p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling
por: Ma, Chao, et al.
Publicado: (2022)

Parkin Levels Decrease in Fibroblasts With Progranulin (PGRN) Pathogenic Variants and in a Cellular Model of PGRN Deficiency
por: Gaweda-Walerych, Katarzyna, et al.
Publicado: (2021)

PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases
por: Zhao, Xiangli, et al.
Publicado: (2022)

Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells
por: Gao, Weihua, et al.
Publicado: (2019)

PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner
por: Wei, Fanhua, et al.
Publicado: (2014)

Mouse-adapted H9N2 avian influenza virus causes systemic infection in mice
por: Hu, Zhe, et al.
Publicado: (2019)

SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus
por: Li, Qiuchen, et al.
Publicado: (2022)

The role of progranulin (PGRN) in the modulation of anti-inflammatory response in asthma
por: Pogonowska, Milena, et al.
Publicado: (2019)

Generation and protective efficacy of a cold-adapted attenuated avian H9N2 influenza vaccine
por: Wei, Yandi, et al.
Publicado: (2016)

Mink is a highly susceptible host species to circulating human and avian influenza viruses
por: Sun, Honglei, et al.
Publicado: (2021)

Isolation and characterization of H4N6 avian influenza viruses from mallard ducks in Beijing, China
por: Hu, Junyi, et al.
Publicado: (2017)

Canine Influenza Virus A(H3N2) Clade with Antigenic Variation, China, 2016–2017
por: Lyu, Yanli, et al.
Publicado: (2019)

N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammals
por: Sun, Honglei, et al.
Publicado: (2022)

Novel Swine Influenza Virus Reassortants in Pigs, China
por: Bi, Yuhai, et al.
Publicado: (2010)

Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS
por: Xiao, Yichuan, et al.
Publicado: (2015)

Thyrotropin Regulates eNOS Expression in the Endothelium by PGRN Through Akt Pathway
por: Jiang, Fengwei, et al.
Publicado: (2018)

A Multiplex RT-PCR Assay for Detection and Differentiation of Avian-Origin Canine H3N2, Equine-Origin H3N8, Human-Origin H3N2, and H1N1/2009 Canine Influenza Viruses
por: Wang, Chenxi, et al.
Publicado: (2017)

Emerging Role of Mucosal Vaccine in Preventing Infection with Avian Influenza A Viruses
por: Wang, Tong, et al.
Publicado: (2020)

The Differential Antiviral Activities of Chicken Interferon α (ChIFN-α) and ChIFN-β are Related to Distinct Interferon-Stimulated Gene Expression
por: Qu, Hongren, et al.
Publicado: (2013)

Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or β-Cell Function in Chinese Obese Children
por: Wang, Fengyun, et al.
Publicado: (2018)

Guinea Pig Model for Evaluating the Potential Public Health Risk of Swine and Avian Influenza Viruses
por: Sun, Yipeng, et al.
Publicado: (2010)

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice
por: Feng, Tuancheng, et al.
Publicado: (2020)

Progranulin (PGRN) as a regulator of inflammation and a critical factor in the immunopathogenesis of cardiovascular diseases
por: Saeedi-Boroujeni, Ali, et al.
Publicado: (2023)

H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans
por: Li, Fangtao, et al.
Publicado: (2021)

GP88/PGRN Serum Levels Are Associated with Prognosis for Oral Squamous Cell Carcinoma Patients
por: Greither, Thomas, et al.
Publicado: (2021)

H9N2 influenza virus in China: a cause of concern
por: Sun, Yipeng, et al.
Publicado: (2014)

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy
por: Zhou, Di, et al.
Publicado: (2019)

Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
por: Wang, Zhen, et al.
Publicado: (2023)

Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza
por: Mallampalli, Rama K., et al.
Publicado: (2021)

Increased public health threat of avian-origin H3N2 influenza virus caused by its evolution in dogs
por: Chen, Mingyue, et al.
Publicado: (2023)

AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM : V. INDUCTION OF INTERFERON BY HELENINE
por: Rytel, Michael W., et al.
Publicado: (1966)

Serological survey of canine H3N2, pandemic H1N1/09, and human seasonal H3N2 influenza viruses in cats in northern China, 2010–2014
por: Zhang, Xuxiao, et al.
Publicado: (2015)

Truncation of C-terminal 20 amino acids in PA-X contributes to adaptation of swine influenza virus in pigs
por: Xu, Guanlong, et al.
Publicado: (2016)

The infection of turkeys and chickens by reassortants derived from pandemic H1N1 2009 and avian H9N2 influenza viruses
por: Sun, Honglei, et al.
Publicado: (2015)

Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals
por: Wang, Chenxi, et al.
Publicado: (2022)

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
por: Götzl, Julia K, et al.
Publicado: (2019)

MiR‐29b‐3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN
por: Chen, Lingqiang, et al.
Publicado: (2017)

Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology
por: Fujita, Kyota, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dajf83bmtm6sauoift5d2fvceu