Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry

Post-translational modifications (PTMs) of therapeutic monoclonal antibodies (mAbs) are important product quality attributes (PQAs) that can potentially impact drug stability, safety, and efficacy. The PTMs of a mAb may change remarkably in the bloodstream after drug administration compared to in vi...

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Detalles Bibliográficos
Autores principales: Xu, Xiaobin, Huang, Yu, Pan, Hao, Molden, Rosalynn, Qiu, Haibo, Daly, Thomas J., Li, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795451/
https://www.ncbi.nlm.nih.gov/pubmed/31618250
http://dx.doi.org/10.1371/journal.pone.0223899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795451/
https://www.ncbi.nlm.nih.gov/pubmed/31618250
http://dx.doi.org/10.1371/journal.pone.0223899

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