PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer

Although nuclear type 2C protein phosphatase (PP2Cδ) has been demonstrated to be pro-oncogenic with an important role in tumorigenesis, the underlying mechanisms that link aberrant PP2Cδ levels with cancer development remain elusive. Here, we found that aberrant PP2Cδ activity decreases p53 acetylat...

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Detalles Bibliográficos
Autores principales: Li, Qun, Hao, Qiongyu, Cao, Wei, Li, Jieqing, Wu, Ke, Elshimali, Yahya, Zhu, Donghui, Chen, Qiao-Hong, Chen, Guanglin, Pollack, Jonathan R., Vadgama, Jay, Wu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795508/
https://www.ncbi.nlm.nih.gov/pubmed/31663018
http://dx.doi.org/10.1126/sciadv.aaw8417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795508/
https://www.ncbi.nlm.nih.gov/pubmed/31663018
http://dx.doi.org/10.1126/sciadv.aaw8417

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