NFAT primes the human RORC locus for RORγt expression in CD4(+) T cells

T helper 17 (Th17) cells have crucial functions in mucosal immunity and the pathogenesis of several chronic inflammatory diseases. The lineage-specific transcription factor, RORγt, encoded by the RORC gene modulates Th17 polarization and function, as well as thymocyte development. Here we define sev...

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Detalles Bibliográficos
Autores principales: Yahia-Cherbal, Hanane, Rybczynska, Magda, Lovecchio, Domenica, Stephen, Tharshana, Lescale, Chloé, Placek, Katarzyna, Larghero, Jérome, Rogge, Lars, Bianchi, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795897/
https://www.ncbi.nlm.nih.gov/pubmed/31619674
http://dx.doi.org/10.1038/s41467-019-12680-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795897/
https://www.ncbi.nlm.nih.gov/pubmed/31619674
http://dx.doi.org/10.1038/s41467-019-12680-x

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