An Altered Splicing Registry Explains the Differential ExSpeU1-Mediated Rescue of Splicing Mutations Causing Haemophilia A

The exon recognition and removal of introns (splicing) from pre-mRNA is a crucial step in the gene expression flow. The process is very complex and therefore susceptible to derangements. Not surprisingly, a significant and still underestimated proportion of disease-causing mutations affects splicing...

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Detalles Bibliográficos
Autores principales: Balestra, Dario, Maestri, Iva, Branchini, Alessio, Ferrarese, Mattia, Bernardi, Francesco, Pinotti, Mirko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796300/
https://www.ncbi.nlm.nih.gov/pubmed/31649737
http://dx.doi.org/10.3389/fgene.2019.00974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796300/
https://www.ncbi.nlm.nih.gov/pubmed/31649737
http://dx.doi.org/10.3389/fgene.2019.00974

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