Cargando…

CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer

BACKGROUND: Emerging evidence has shown that circular RNAs (circRNAs) play essential roles in cancer biology and are potential biomarkers and targets for cancer therapy. However, the expression and function of circRNAs in ovarian carcinogenesis and its progression remain elusive. METHODS: RNA sequen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Lei, Zhou, Qing, Qiu, Qiongzi, Hou, Ling, Wu, Mengting, Li, Jia, Li, Xufan, Lu, Bingjian, Cheng, Xiaodong, Liu, Pengyuan, Lu, Weiguo, Lu, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796346/ https://www.ncbi.nlm.nih.gov/pubmed/31623606 http://dx.doi.org/10.1186/s12943-019-1080-5

Ejemplares similares

circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer
por: Wu, Mengting, et al.
Publicado: (2022)

LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation
por: Luo, Aoran, et al.
Publicado: (2022)

LCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC
por: Qian, Xinyi, et al.
Publicado: (2021)

Long noncoding RNA LCAT1 functions as a ceRNA to regulate RAC1 function by sponging miR-4715-5p in lung cancer
por: Yang, Juze, et al.
Publicado: (2019)

Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis
por: Sun, Sifan, et al.
Publicado: (2021)

TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption
por: Witwicka, Hanna, et al.
Publicado: (2015)

LIS1 Regulates Osteoclast Formation and Function through Its Interactions with Dynein/Dynactin and Plekhm1
por: Ye, Shiqiao, et al.
Publicado: (2011)

CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression
por: Xu, Junfen, et al.
Publicado: (2021)

Integrated analysis of DNA methylome and transcriptome reveals SFRP1 and LIPG as potential drivers of ovarian cancer metastasis
por: Yi, Jiani, et al.
Publicado: (2023)

The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes
por: Marwaha, Rituraj, et al.
Publicado: (2017)

CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9
por: He, Qingqing, et al.
Publicado: (2019)

The Molecular Chaperone DNAJB6, but Not DNAJB1, Suppresses the Seeded Aggregation of Alpha-Synuclein in Cells
por: Deshayes, Natasja, et al.
Publicado: (2019)

Increased circulating GrMyeloid-derived suppressor cells correlated with tumor burden and survival in locally advanced cervical cancer patient
por: Liang, Yun, et al.
Publicado: (2019)

Smoker and non-smoker lung adenocarcinoma is characterized by distinct tumor immune microenvironments
por: Li, Xufan, et al.
Publicado: (2018)

Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer
por: Zhou, Liyuan, et al.
Publicado: (2022)

Global identification and characterization of tRNA-derived RNA fragment landscapes across human cancers
por: Sun, Xiwei, et al.
Publicado: (2020)

Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain
por: Tabata, Keisuke, et al.
Publicado: (2010)

BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis
por: Li, Qianyan, et al.
Publicado: (2021)

LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis
por: Yang, Juze, et al.
Publicado: (2022)

Development of survival predictors for high-grade serous ovarian cancer based on stable radiomic features from computed tomography images
por: Hu, Jiaqi, et al.
Publicado: (2022)

Structure-Function of the Tumor Suppressor BRCA1
por: Clark, Serena L., et al.
Publicado: (2012)

PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux
por: Ben-Zvi, Hadas, et al.
Publicado: (2022)

miR-1205/DNAJB1 reverses docetaxel chemoresistance in human triple negative breast carcinoma cells via regulation of mutp53/TAp63 signaling: miR-1205/DNAJB1 reverses docetaxel chemoresistance in TNBC
por: Yin, Yongxiang, et al.
Publicado: (2021)

circPSMC3: ceRNA and tumor suppressor
por: Lu, Chen, et al.
Publicado: (2019)

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
por: Tacconi, Eliana MC, et al.
Publicado: (2017)

Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV
por: Ko, Shih-Han, et al.
Publicado: (2018)

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway
por: Sousa, Luis, et al.
Publicado: (2020)

DNAJB6b is Downregulated in Synucleinopathies
por: Folke, Jonas, et al.
Publicado: (2021)

On the micelle formation of DNAJB6b
por: Carlsson, Andreas, et al.
Publicado: (2023)

BRCA1 tumor suppressor network: focusing on its tail
por: Wang, Bin
Publicado: (2012)

BRCA1 as tumor suppressor: lord without its RING?
por: Elia, Andrew EH, et al.
Publicado: (2012)

Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1
por: Berthel, Elise, et al.
Publicado: (2020)

The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin
por: Wang, Zehao, et al.
Publicado: (2022)

A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function
por: Kononenko, Artem V., et al.
Publicado: (2014)

BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development
por: Kitami, Kohei, et al.
Publicado: (2018)

Diagnostically important muscle pathology in DNAJB6 mutated LGMD1D
por: Sandell, Satu, et al.
Publicado: (2016)

Genotypic and Phenotypic Heterogeneity of LGMD1D due to DNAJB6 Mutations
por: Finsterer, Josef
Publicado: (2018)

Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation
por: Rodríguez-González, Claudio, et al.
Publicado: (2020)

Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA
por: Neumayer, Christoph, et al.
Publicado: (2023)

miR-2861 acts as a tumor suppressor via targeting EGFR/AKT2/CCND1 pathway in cervical cancer induced by human papillomavirus virus 16 E6
por: Xu, Junfen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_n4bp6tjnh8hsf2vc2reud604au