De Novo Isolation & Affinity Maturation of yeast-displayed Virion-binding human fibronectin domains by flow cytometric screening against Virions

BACKGROUND: The promise of biopharmaceuticals comprising one or more binding domains motivates the development of novel methods for de novo isolation and affinity maturation of virion-binding domains. Identifying avenues for overcoming the challenges associated with using virions as screening reagen...

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Detalles Bibliográficos
Autores principales: Heinzelman, Pete, Low, Alyssa, Simeon, Rudo, Wright, Gus A., Chen, Zhilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796422/
https://www.ncbi.nlm.nih.gov/pubmed/31636701
http://dx.doi.org/10.1186/s13036-019-0203-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796422/
https://www.ncbi.nlm.nih.gov/pubmed/31636701
http://dx.doi.org/10.1186/s13036-019-0203-2

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