STAT3 induces G9a to exacerbate HER3 expression for the survival of epidermal growth factor receptor-tyrosine kinase inhibitors in lung cancers

BACKGROUND: HER3 mediates drug resistance against epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), resulting in tumor relapse in lung cancers. Previously, we demonstrated that EGFR induces HER3 overexpression, which facilitates the formation of cancer stem-like tumorspheres...

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Detalles Bibliográficos
Autores principales: Chang, Yi-Fang, Lim, Ken-Hong, Chiang, Ya-Wen, Sie, Zong-Lin, Chang, Jungshan, Ho, Ai-Sheng, Cheng, Chun-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796430/
https://www.ncbi.nlm.nih.gov/pubmed/31619200
http://dx.doi.org/10.1186/s12885-019-6217-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796430/
https://www.ncbi.nlm.nih.gov/pubmed/31619200
http://dx.doi.org/10.1186/s12885-019-6217-9

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