Benzene metabolites trigger pyroptosis and contribute to haematotoxicity via TET2 directly regulating the Aim2/Casp1 pathway

BACKGROUND: Long term low-dose benzene exposure leads to the inhibition of haematopoiesis. However, the underlying mechanisms remained poorly defined, especially mediated by early effector molecules. METHODS: Here, we first found in mRNA microarray that pyroptotic classic genes (Casp1, 4, 5, and IL1...

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Detalles Bibliográficos
Autores principales: Guo, Xiaoli, Zhong, Wen, Chen, Yujiao, Zhang, Wei, Ren, Jing, Gao, Ai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796562/
https://www.ncbi.nlm.nih.gov/pubmed/31474553
http://dx.doi.org/10.1016/j.ebiom.2019.08.056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796562/
https://www.ncbi.nlm.nih.gov/pubmed/31474553
http://dx.doi.org/10.1016/j.ebiom.2019.08.056

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