Dual lysosomal-mitochondrial targeting by antihistamines to eradicate leukaemic cells

BACKGROUND: Despite great efforts to identify druggable molecular targets for AML, there remains an unmet need for more effective therapies. METHODS: An in silico screening was performed using Connectivity Maps to identify FDA-approved drugs that may revert an early leukaemic transformation gene sig...

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Detalles Bibliográficos
Autores principales: Cornet-Masana, Josep M., Banús-Mulet, Antònia, Carbó, José M., Torrente, Miguel Ángel, Guijarro, Francesca, Cuesta-Casanovas, Laia, Esteve, Jordi, Risueño, Ruth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796581/
https://www.ncbi.nlm.nih.gov/pubmed/31473184
http://dx.doi.org/10.1016/j.ebiom.2019.08.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796581/
https://www.ncbi.nlm.nih.gov/pubmed/31473184
http://dx.doi.org/10.1016/j.ebiom.2019.08.021

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