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Dual lysosomal-mitochondrial targeting by antihistamines to eradicate leukaemic cells
BACKGROUND: Despite great efforts to identify druggable molecular targets for AML, there remains an unmet need for more effective therapies. METHODS: An in silico screening was performed using Connectivity Maps to identify FDA-approved drugs that may revert an early leukaemic transformation gene sig...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796581/ https://www.ncbi.nlm.nih.gov/pubmed/31473184 http://dx.doi.org/10.1016/j.ebiom.2019.08.021 |