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Studying Interactions between 2’-O-Me-Modified Inhibitors and MicroRNAs Utilizing Microscale Thermophoresis

Besides the acquisition of pharmacokinetic parameters of antisense oligonucleotide microRNA (miRNA) inhibitors, such as measuring in vivo concentration, their pharmacodynamic characteristics are also of interest. An emerging and straightforward method for studying molecular interactions is microscal...

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Detalles Bibliográficos
Autores principales: Herkt, Markus, Batkai, Sandor, Thum, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796726/
https://www.ncbi.nlm.nih.gov/pubmed/31581050
http://dx.doi.org/10.1016/j.omtn.2019.08.019