Therapy with 2′-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption

Antisense oligonucleotide therapy has been reported to be associated with renal injury. Here, the mechanism of reversible proteinuria was investigated by combining clinical, pre-clinical, and in vitro data. Urine samples were obtained from Duchenne muscular dystrophy (DMD) patients treated with dris...

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Detalles Bibliográficos
Autores principales: Janssen, Manoe J., Nieskens, Tom T.G., Steevels, Tessa A.M., Caetano-Pinto, Pedro, den Braanker, Dirk, Mulder, Melissa, Ponstein, Yolanda, Jones, Shaun, Masereeuw, Rosalinde, den Besten, Cathaline, Wilmer, Martijn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796739/
https://www.ncbi.nlm.nih.gov/pubmed/31610379
http://dx.doi.org/10.1016/j.omtn.2019.08.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796739/
https://www.ncbi.nlm.nih.gov/pubmed/31610379
http://dx.doi.org/10.1016/j.omtn.2019.08.025

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